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In high transmission areas, partial immunity to the disease is acquired during childhood.In such settings, the majority of malarial disease, and particularly severe disease with rapid progression to death, occurs in young children without acquired immunity.
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Worldwide, the number of cases of malaria caused by , a less virulent form of the parasite.
Furthermore, mosquitoes are becoming increasingly resistant to insecticides, and in many cases, have adapted so as to avoid insecticide-treated surfaces altogether.
Although often considered a single disease, malaria is more accurately viewed as many diseases, each shaped by subtle interactions of biologic, ecologic, social, and economic factors.
The species of parasite, the behavior of the mosquito host, the individual's immune status, the climate, human activities, and access to health services all play important roles in determining the intensity of disease transmission, who will become infected, who will get sick, and who will die.
The dream of completely eliminating malaria from many parts of the world, pursued with vigor during the 1950s and 1960s, has gradually faded.
Few believe today that a global eradication of malaria will be possible in the foreseeable future.
For infants weighing less than 5 kg with uncomplicated Because the clinical condition of children with malaria can deteriorate rapidly, there should be a low threshold for the use of parenteral treatment.
Recent data support the use of intravenous artesunate in preference to artemether or quinine for the treatment of severe malaria in children.